Innovative Self-Monitoring Glucose Device

ABS is developing a revolutionary hand-held glucose meter with innovative characteristics and patient benefits.  The Little Deer device can measure glucose in a variety of specimens including: whole blood, serum or a venous blood specimen with sub micro liter range volumes.  

Using the latest in nanotechnology, glucose in the specimen is measured using a sensor chip with a unique membrane.  An electrical voltage is applied to the sensor chip which generates current that is proportional to the glucose concentration. These electrochemical reactions do not produce any waste material and eliminate the need to add reagent to the chip.  The end result is a device that is accurate, precise, fast and sensitive that is environmentally friendly as well as improved cost-effectiveness for patients. 

While this device will clearly benefit all diabetic patients, it will be especially beneficial for children.  Furthermore, because our device is exceptionally accurate at the low end of the blood glucose concentration, it is extremely useful in the prevention of hypoglycemia episode.  Diabetes patients can check themselves before and after exercise or other activities, preventing dangerously low levels of hypoglycemia and the resulting coma and increased risk of death. 

Nanobiomimetic Reagent-Less Detection And Therapeutic Monitoring Devices 

ABS’s nanobiomimetic reagent-less devices are capable of distinguishing a single subtype breast cancer cell from normal cells and are able for therapeutic functions.These sensors have also shown selectivity among different types of cancer cells.  Each of these devices is in the prototype stage. 

Publications in Medical Device Developments and Research 

E. T. Chen, J. T. Thornton, S-H. Duh and P. T. Kissinger,  Observation of Fermi Arc Surface States Induced by Organic Memristive/Memcapacitive Devices with a Double-Helical Polarized Single-Wall Nanotube Membrane for Direct Chelating with Matrix Matelloproteinase-2, Sensors & Transducers, 214(7), 69-84, 2017. 

 E. T. Chen, J. T. Thornton, S-H. Duh and P.T. Kissinger will give a presentation titled “Organic Nanobiomimetic Memristive/Memcapacitive Devices Ultrasensitive Direct Detect Matrix Matelloproteinase-2 in Human Serum” Biotech, Biomaterials and Biomedical, TechConnect Briefs, 271-274, 2017.   

S-H. Duh,  J. Thornton, P.T. Kissinger and E. T. Chen, Nanobiomimetic memristor/memcapacitor devices used for direct and reagent-less detection of sub pM acetyl coenzyme A in milks, Sensors, Diagnostics & Imaging, TechConnect Briefs, 4, 136-139, 2016.

S-H. Duh, J. Thornton, P.T. Kissinger and E. T. Chen,  Nanobiomimetic Memristor/memcapacitors’ Function as a Voltage Sensor for Direct and Reagent-free Detection of sub pg Lipopolysaccharide (LPS) in Different Types of Milks for Infants, Sensors, Diagnostics & Imaging,  TechConnect Briefs, 4, 140-143, 2016.

http://www.techconnectworld.com

S-H. Duh, J. Thornton, P. T. Kissinger and E. T. Chen,  Human Milk Shows Immunological Advantages Over Organic Milk Samples For Infants In the Presence of  Lipopolysaccharide (LPS) in 3D Energy Maps Using an Organic Nanobiomimetic Memristor/Memcapacitor, Sensors & Transducers, 203(8), 57-68, 2016. http://www.sensorsportal.com/HTML/DIGEST/New_Digest.htm

 E. T. Chen, J. Thornton, P. T. Kissinger and S-H. Duh, The Advantages of Human Milk Recognize the Spatiotemporal Locations of Toxins and Intelligently Bypass Them by Forming a Hummingbird-Like Hovering Neural Network Circuitry Based on An Organic Biomimetic Choline Acetyltransferase Memristor/Memcapacitor Prosthesis, Sensors & Transducers, 203(8), 69-83, 2016.  http://www.sensorsportal.com/HTML/DIGEST/New_Digest.htm

Duh S-H, Thornton J, Kissinger PT and Chen ET,  A Nanobiomimetic Neuronal Memcapacitor Serves as a Voltage Sensor and an Amperometry Sensor for Reagent-less Direct Detection of Sub pM Soluble Amyloid-beta. Biotech, Biomaterials and Biomedical: TechConnect Briefs, 172-175, 2015. 

Chen ET, Thornton J and Mulchi Jr C, Nanobiomimetic Memcapacitor Memory Devices Identify Circadian Rhythm Dysfunction and Predict Early Signs of “Epilepsy” Using Reentrant Energy-Sensory Images, Advanced Manufacturing, Electronics and Microsystems: TechConnect Briefs, 200-203, 2015

Thornton J, Mulchi, Jr.C, Kissinger PT and  Chen ET,  Acetylcholine Repairs the Amyloid-beta Damage on Brain Circuitry and Memory Loss From a “Mutated Biomimetic Acetylcholinesterase” Neuronal Memcapacitor During Slow-Wave Sleeping, Advanced Manufacturing, Electronics and Microsystems: TechConnect Briefs, 226-229, 2015

Chen ET, Thornton JT and Mulchi, Jr.C., Early Forming a Hummingbird-like Hovering Neural Network Circuitry Pattern with Reentrant Spatiotemporal Energy-Sensory Orientation Privileged to Avoid “Epilepsy” Based on a Biomimetic Acetylcholinesterase Memcapacitor Prosthesis, Sensors and Transducers Journal, 191(8), 84-99, 2015.

Thornton JT, Mulchi, Jr.C, Kissinger PT,  Chen ET, In Vitro Restoration of an Amyloid-Beta Altered Network Circuitry in a 'Mutated Biomimetic Acetylcholinesterase' Memristor/Memcapacitor Neural Prosthesis, Sensors and Transducers Journal, 191(8), 100-113, 2015.

Chen ET, Thornton J and Mulchi Jr C. Mapping Circular Current for a Single Brain Cancer Cell’s Spatial-Temporal Orientations Based on a Memristor/Memcapacitor, Sensors & Transducers, 183(12), 72-83, 2014, an invited paper by the Editor-in-chief..

Chen ET, Thornton J, Ngatchou C and Duh S-H. presented the research results in a professional talk #1088, titled of Nanostructured Memristor Sensor Mimics Acetylcholinesterase (ACHE) Active Sites In The Gorge For fM Detection Of Acetylcholine at the Tech Connect World conference www.techconnectworld.com at Washington DC, in June, 2014.  The article was published in the journal of NSTi-Nanotech, 2, 200-203, 2014

Chen ET, Thornton J, Ngatchou C, Duh S-H and Kissinger PT. presented the research results in a poster #1065, titled Nanostructured Biomimetic Memristor Sensors Used For Therapeutic Monitoring Of The Brain Cancer at the Tech Connect World conference at Washington DC, in June, 2014.  The article was published in the journal of NSTi-Nanotech, 2, 169-172, 2014.  

E. T. Chen, J. Thornton, C. Christelle, S-H. Duh and P. Kissinger, Nanostructured       Biomimetic Pyruvate Dehydrogenase Complex (PDC) Sensors Selectively Detect       Single Brain Cancer Cells Having The Ability To Mimic The “ATP Lid”, was                 published in the peer-reviewed journal of NSTi-Nanotech (3), 115-118, 2013.

 
E. T. Chen, J. Thornton, C. Christelle, S-H. Duh and P. Kissinger, Study of the Correlations Between Direct Electron Transfer Rate Constants And The Effectiveness Of Cancer Inhibitors Using Nanobiomimetic Sensors, was published in the peer-reviewed journal of NSTi- NanoTech (2), 107-110, 2013.  
 
A Chapter with the lead author Chen ET,  titled of Biomimetic sensing and energy storage was appeared in the first volume, in the  third edition of Dekker Encyclopedia of Nanoscience and Nanotechnology on March 20, 2014  at www.crcpress.com.  The Editor was  Lyshevski SE. 
 
E. Chen, Y. Shen J. Thorten, C. Ngatchou, S-H. Duh and P.T. Kissinger, A Nanopore Biomimetic device quantitatively detects early stage cancer cells; a Contour Map Multiple Variable Correlation Method assesses the heat of cancer cells released, Nanotech 198-201, 2012.

E. Chen, Y. Shen J. Thorten, C. Ngatchou, S-H. Duh and P.T. Kissinger, A nanopore structured Biomimetic sensor device induced early stage cancer cells for direct bio-communication, American Chemical Society annual fall national meeting Abstract Book, 2012.

E. Chen, S-h Duh, C.Ngatchou, J. T. Thornton and P.T. Kissinger, Selectivity Study for a Reagent-less and Enzyme-free Nanopore Glucose Sensor Against Interferences from Non-glucose Sugars and Other Substances, Nanotech (3),101-104, 2011.

Presentations in Medical Device Development and Research

E. T. Chen, J. T. Thornton, S-H. Duh and P.T. Kissinger had a presentation titled “Organic Nanobiomimetic Memristive/Memcapacitive Devices Ultrasensitive Direct Detect Matrix Matelloproteinase-2 in Human Serum” on Wednesday, May 17, 2017 at the Gaylord Convention center at the Techconnect World conference www.techconnectworld.com.  The article was published in the Proceedings of TechConnect Briefs in Sensors, May 15, 2017. 

S-H. Duh, J. Thornton, P.T. Kissinger, E.T. Chen had an oral presentation titled “ Nanobiomimetic Memristor/Memcapacitor Devices Used for Direct and Reagent-less Detection of Sub pM Acetyl Coenzyme A in Milks” at the Tech Connect World conference www.techconnectworld.com on Wednesday at W1.333, May 25, 2016 at the Gaylord Convention center.  The article was published in the Proceedings of TechConnect Briefs, May 22, 2016.

S-H. Duh, J. Thornton, P.T. Kissinger, E.T. Chen had an oral presentation titled “Nanobiomimetic Memristor/memcapacitors’ Function as a Voltage Sensor for Direct and Reagent-free Detection of sub pg Lipopolysaccharide (LPS) in Milks for Children” at the Techconnect World conference www.techconnectworld.com on Wednesday at W3.333, May 25, 2016 at the Gaylord Convention center. The article was published in the Proceedings of TechConnect Briefs, May 22, 2016.

Duh S-H, Thornton J, Kissinger PT and Chen ET presented a professional talk # WE4.185 in the title of A Nanobiomimetic Neuronal Memcapacitor Serves as a Voltage Sensor and an Amperometry Sensor for Reagent-less Direct Detection of Sub pM Soluble Amyloid-beta at the Tech Connect World Conference www.techconnectworld.com at Washington DC in June, 2015. The article will be published in the journal of NSTi-Nanotech, 2015.

Chen ET, Thornton J and Mulchi Jr C. presented a professional poster # TU6.068 in the title of  Nanobiomimetic Memcapacitor Memory Devices Identify Circadian Rhythm Dysfunction and Predict Early Signs of “Epilepsy” Using Reentrant Energy-Sensory Images at the Tech Connect World Conference at Washington DC in June,  2015. The article will be published in NSTi-Nanotech, 2015

Thornton J, Mulchi, Jr.C, Kissinger PT and  Chen ET, presented a professional poster WE5.890 in titled of Acetylcholine Repairs the Amyloid-beta Damage on Brain Circuitry and Memory Loss From a “Mutated Biomimetic Acetylcholinesterase” Neuronal Memcapacitor During Slow-Wave Sleeping at the Tech Connect World Conference in June, 2015 at Washington DC Gaylord Convention Center. The article will be published in the journal of NSTi-Nanotech, 2015.

ABS once again has been honored by the National Innovation Showcase Committee chosen as the National Innovation Showcase and the International Innovation Showcase in lists at show booth # 47T for our Nanobiomimetic Reagent-free technology platform at the Tech Connect World Conference on June 15-17, 2015 at Washington DC Gaylord Convention Center. 

E. T. Chen J. Thornton, C. Ngatchou1, S-H. Duh and P.T. Kissinger presented a poster in the title of Portable and Low-Cost Highly Selective and Sensitive Subtype Breast Cancer Biosensing with Real Time Cancer Prognosis Heat Mapping Monitoring for Global Health at  the Cancer Detection, Diagnostic and Treatment Technologies for Global Health conference at NIH, Bethesda, Maryland from January 8-10, 2014.

ABS presented our research results in a professional talk #1088, titled of Nanostructured Memristor Sensor Mimics Acetylcholinesterase (ACHE) Active Sites In The Gorge For fM Detection Of Acetylcholine at the Tech Connect World conference www.techconnectworld.com at Washington DC, in June, 2014. 

ABS presented our research results in a poster #1065, titled Nanostructured Biomimetic Memristor Sensors Used For Therapeutic Monitoring Of The Brain Cancer at the Tech Connect World conference at Washington DC, in June, 2014.  

An oral presentation from ABS at #1362 titled of Nanostructured Biomimetic Pyruvate Dehydrogenase Complex (PDC) Sensors Selectively Detect Single Brain Cancer Cell Having The Ability To Mimic The “ATP Lid” was one of the two companies among the international applicants chosen presented at the NNI signature initiative symposium on Nanotechnology for sensors and sensors for nanotechnology announced by the Symposium Chairman Dr. Honda Chen, who is the National Program Leader NIFA at the Tech Connect World Conference, Washington, DC, Gaylord Convention Center, May 15, 2013.  http://www.techconnectworld.com/Nanotech2013/sym/nanotechnology_sensors.html

 
   A poster from ABS at #1252 titled of Study Of The Correlations Between Direct Electron Transfer Rate Constants And The Effectiveness Of Cancer Inhibitors was presented at the Tech Connect World conference, Washington, DC, Gaylord Convention Center, May 14, 2013.  
 
A poster from ABS titled of A Dual-function Nanopore Biomimetic Device Quantitatively Detects Single Breast Cancer Cells; a Contour Map of Multiple Variable Correlation Method Assesses the Heat Released by Cancer Cells will be presented at the NIH Single Cell Investigator’s conference from April 15-16, 2013 at Bethesda, Maryland.
 
ABS had a show booth #818 at the National Innovation Showcase at the Tech Connect World conference, Washington, DC, Gaylord Convention Center, May 15-16, 2013.  
 
An oral presentation in the topic of A nanopore structured Biomimetic sensor device induced early stage cancer cells for direct bio-communication by Dr. E. Chen, American Chemical Society Annual National Meeting August 19-23, Philadulphia, 2012.

 An oral presentation at the international Tech Connect World conference, Dr. E. Chen gave a presentation in the topic of single cancer cell detection device, Santa Clara, CA, June 22, 2012.

Presentations in Business Showcase in Medical Devices

ABS once again has been honored by the National Innovation Showcase Committee chosen as the National Innovation Showcase and the International Innovation Showcase in lists at booth # 5M for our Nanobiomimetic Sensing and Energy Storage platform technology at the Tech Connect World Conference on May 15-16, 2017 at Washington DC Gaylord Convention Center. 

 Dr. E. Chen had a business presentation in Biomedical Innovation Spotlights on Wednesday, May 17, 2017 at the Gaylord Convention center at the Techconnect World conference.

ABS once again has been honored by the National Innovation Showcase Committee chosen as the National Innovation Showcase and the International Innovation Showcase in lists at booth # 45M for our Nanobiomimetic Reagent-free technology platform at the Tech Connect World Conference on May 23, 2016 at Washington DC Gaylord Convention Center. 

ABS once again has been honored by the National Innovation Showcase Committee chosen as the National Innovation Showcase and the International Innovation Showcase in lists at show booth # 47T for our Nanobiomimetic Reagent-free technology platform at the Tech Connect World Conference on June 15-17, 2015 at Washington DC Gaylord Convention Center. 

ABS once again was honored by the National Innovation Showcase Committee chosen as the National Innovation Showcase for our Nanobiomimetic Reagent-free technology platform at the Tech Connect World Conference in June 2014 at Washington DC.  

ABS will present its show booth #818 at the National Innovation Showcase at Tech Connect World conference, Washington DC, May 15-16, 2013.
 

 A business pitch presented by Dr. E. Chen, A nanopore Biomimetic medical device platform, Tech Connect World conference, June 19-23, Santa Clara, CA, 2012.

Dr. E.Chen presented a trade show on behalf of ABS, Inc. The Nanobiomimetic medical devices platform technologies at the National Innovation Showcase, TEch Connect World Conference, Santa Clare, CA, June 21, 2012.

Patent Issued

Nanopore Structured Electrochemical Biosensor, issued by the USPTO # 8,083,926 on December 27, 2011. The inventor was E. Chen.

A new patent # 8,632,925 was issued in the title of Apparatus and Methods for Making High Performance Fuel Cell by the US Patent Office on January 21, 2014. 

A new patent # 8,641,876 in the title of Nanopore Array Structured Devices for Biosensing and Energy Storage was issued by the US Patent Office on February 4, 2014.  

A US Patent No. 9,443,665 was granted in the title of Nanobiomimetic supercapacitors with high rate high energy storage was issued on September 13, 2016 by the US Patent and Trademark Office. 

Another US Patent No. 9,534,999 was granted in the tile of A nanostructured biomimetic device for detecting a cancer cell or cancer cells and was issued by the US Patent and Trademark Office on January 3, 2017.

The US Patent and Trade Office issued a Notice of Allowance to the US patent application No.14/919, 606 on June 7, 2017.  The new patent no. 9,793,503 was issued on October 17, 2017.